Tirzepatide Liposomal Chewable Tablet Dosing Guide

This guide is for educational purposes only and applies only to the compounded Tirzepatide liposomal chewable tablet formulation described here. It does not replace advice from your healthcare provider. Always follow the dose and instructions provided with your prescription. Read the full medical disclaimer

Tirzepatide liposomal chewable tablets are a compounded oral formulation supplied as 3 mg scored tablets. The dosing instructions below apply only to this specific formulation and should not be used as a dosing guide for FDA-approved injectable tirzepatide products.

The liposomal delivery approach described for this formulation is based on general drug-delivery literature. Its absorption, effectiveness, and clinical benefits have not been independently established in clinical studies of this specific compounded product.

How to Take Tirzepatide Chewable Tablets

• Chew and swallow 1 tablet once daily for the first 4 weeks.
• The tablet may be taken with or without food.
• If your healthcare provider determines that an increase is appropriate, the dose may be increased by ½ tablet every 4 weeks.
• The supplied formulation has a maximum dose of 2 tablets daily (6 mg).
• Your provider may modify or delay dose increases based on your response and tolerability.

Important: Do not increase your dose or take additional tablets without instructions from your healthcare provider.

Dose and Titration

Each scored tablet contains 3 mg of tirzepatide.

The goal of titration is to identify a dose that is appropriate and tolerated for you. Not every patient will require the maximum dose.

If You Miss a Dose

Follow the missed-dose instructions provided by your healthcare provider or dispensing pharmacy. Do not double your next dose or take extra tablets unless specifically instructed.

If You Do Not Notice a Difference

Individual responses can vary. Do not take additional tablets because you feel the medication is not working. Talk with your healthcare provider before changing your dose.

If You Have Side Effects

Common gastrointestinal side effects may include:

• Nausea
• Diarrhea
• Constipation
• Vomiting
• Acid reflux
• Stomach discomfort

If symptoms are severe, persistent, or worsening, contact your healthcare provider. Persistent vomiting or diarrhea can lead to dehydration.

Important Safety Information

Thyroid C-cell tumors: Do not use tirzepatide if you or a family member has medullary thyroid carcinoma (MTC) or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tirzepatide has caused thyroid C-cell tumors in rodents, but it is unknown whether this occurs in humans.

Serious allergic reactions: Tell your healthcare provider if you have previously experienced a serious allergic reaction to tirzepatide or any ingredient in your medication. Seek immediate medical attention for symptoms of a serious allergic reaction, such as swelling of the face or throat or difficulty breathing.

Pancreatitis: Contact your healthcare provider promptly if you develop severe or persistent abdominal pain, particularly if it radiates to your back and may occur with nausea or vomiting.

Gallbladder problems: Contact your healthcare provider if you develop symptoms that may indicate gallbladder disease, including persistent abdominal pain, particularly with nausea or vomiting.

Gastrointestinal effects: Tirzepatide can cause gastrointestinal adverse reactions, which may sometimes be severe. It is not recommended for people with severe gastroparesis.

Dehydration and kidney problems: Vomiting or diarrhea can cause fluid loss and may affect kidney function. Maintain adequate fluid intake and contact your provider if these symptoms are persistent.

Low blood sugar: The risk of hypoglycemia may increase when tirzepatide is used with insulin or certain medications that stimulate insulin release. Tell your provider about all diabetes medications you take.

Diabetic retinopathy: If you have diabetes and a history of diabetic retinopathy, tell your healthcare provider and report new or worsening vision changes.

Surgery or sedation: Tirzepatide delays gastric emptying. Tell your healthcare team that you take tirzepatide before any planned surgery or procedure requiring general anesthesia or deep sedation.

Other GLP-1 medications

Do not combine tirzepatide with another GLP-1 receptor agonist or another tirzepatide-containing medication unless specifically directed by your healthcare provider.

Pregnancy, Breastfeeding, and Birth Control

Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

For FDA-approved tirzepatide, pregnancy is a reason to discontinue treatment because of potential fetal harm. The safety of this compounded liposomal chewable formulation during pregnancy and breastfeeding has not been established.

Tirzepatide can delay gastric emptying and may affect the absorption of oral medications. If you use an oral hormonal contraceptive, discuss contraceptive options with your healthcare provider, particularly when starting treatment or after a dose increase. The FDA-approved tirzepatide label recommends a non-oral contraceptive method or an additional barrier method for 4 weeks after initiation and for 4 weeks after each dose escalation.

Storage

Store the tablets at 68°F to 77°F (20°C to 25°C) unless your dispensing pharmacy provides different instructions.

Do not use the medication after the pharmacy-provided 180-day beyond-use date.

Compounded Medication Disclaimer

This product is a compounded medication and is not FDA-approved. Compounded medications are not reviewed by the FDA for safety, effectiveness, or quality before marketing. They should be used only when appropriate for an individual patient's medical needs and under the direction of a licensed healthcare professional.

The dosing information on this page applies only to the specific 3 mg Tirzepatide Liposomal Chewable Tablet formulation described here. The potential benefits of tirzepatide described in general medical literature should not be interpreted as evidence that this specific compounded oral formulation has been clinically proven to provide the same effects.

Always follow the prescription and instructions provided by your healthcare provider and dispensing pharmacy. Do not change your dose, stop treatment, or combine medications without consulting your provider.